"The dose makes the poison" (Latin: dosis sola facit venenum 'only the dose makes the poison') is an adage intended to indicate a basic principle of toxicology. It is credited to Paracelsus who expressed the classic toxicology maxim "All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison." (Sola dosis facit venenum "Only the dose makes the poison") This was used to defend his use of inorganic substances in medicine as outsiders frequently criticized Paracelsus's chemical agents as too toxic to be used as therapeutic agents. His belief that diseases locate in a specific organ was extended to inclusion of target organ.
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sola dosis facit venemum Phrase Meaning: the dose makes the poison. Comment. It is credited to Paracelsus who expressed the classic toxicology maxim "All things are poison and nothing is without poison; only the dose makes a thing not a poison." Word-for-word analysis: The phrase "sola dosis facit venenum," (usually rendered "the dose makes the poison" in English) is a Latinization of the German phrase above from Paracelsus. He wrote this in his "Seven Defenses" when he was fighting against accusations of poisoning his patients 3 (malpractice court, it seems, is one of the oldest traditions in medicine). 'Sola dosis facit venenum' (Latin: all things are poison and nothing is without poison; only the dose makes a thing not a poison)—Paracelsus (1493-1541). The title of this article is: "Sola Dosis Facit Venenum," which means that the dose makes the poison. Consequently, if one wants to do therapy in nuclear medicine, dosimetry is mandatory. Dosimetry adds a lot of important information to clinical and medical facts in order to find the optimal therapeutic path for each individual patient.
Dosis sola facit venenum
Richard Levins's (Am Sci 54(4):421-431, 1966) paper sets a landmark for the significance of scientific model-making in biology. Colombo and Palacios (Biol Philos 36(5):1-26. 10.1007/S10539-021-09818-X, 2021) have recently built their critique of the explanatory power of the Free Energy Principle on Levins's insight into the relationship between generality, realism, and precision. This. Paracelsus is best remembered for this declaration: Dosis sola facit venenum. "The poison is in the dose." More than 500 years later, it's a principle reporters and environmentalists constantly. 'Allein die dosis macht das ein ding kein gift ist'/Sola dosis facit venenum. Similar wisdom in the context of pharmacology came from the Swiss-German physician Theophrastus of Hohenheim (Paracelsus) whose use of poisons, such as opium, to treat the sick resulted in accusations against him by academics in Basel.. Dosis sola facit enenum reconceptualising biological… Page 3 of 18 54 The free energy principle and biological realism According to the second law of thermodynamics, the sum of entropies of all of the systems partaking in a thermodynamic process would increase. In order to survive,
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DISCUSSION. TCA intoxication presents with a variety of symptoms ranging in severity from mild nausea and headache to seizure, respiratory distress, or fatal arrythmia. Our patient presented with lethargy, but the severity of her TCA intoxication was clouded by her combined alcohol ingestion. Sola dosis facit venenum FJT Staal et al 1850 Leukemia. serial transplantations remarkably increase the sensitivity of detecting genotoxic effects of viral vectors.20,21 In this report,
The closest thing is unica dosis est, quae veneno caret, which kind of conveys the same idea but has a slightly different meaning. If this wikipedia page and the larger context it gives (preceding sentence: "All things are poison and nothing is without poison;.") is to be believed, then the quote I mentioned above does indeed seem to be the origin of more popular sola dosis/dosis sola facit. All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison. —Paracelsus, 1538 [1] " The dose makes the poison " ( Latin: dosis sola facit venenum 'only the dose makes the poison') is an adage intended to indicate a basic principle of toxicology. It is credited to Paracelsus who expressed the.
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Request PDF | Dosis sola facit venenum: reconceptualising biological realism | Richard Levins's (Am Sci 54(4):421-431, 1966) paper sets a landmark for the significance of scientific model. Dosis sola facit venenum: reconceptualising biological realism. This paper addresses the issue of the plausibility of biological explanations that are grounded in the Free Energy Principle (FEP) and deals with the question of the realist fortitude of FEP's theoretical framework.
