This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase FTO is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first mRNA demethylase that has been identified. [5]
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The fat mass and obesity-associated ( FTO) rs9939609 A allele has been associated with obesity and dietary energy intakes in healthy children but its relation to metabolic complications in SGA-treated children is not known. Objectives Background: Children with rs9939609 FTO variant alleles (homozygous = AA and heterozygous = AT) are predisposed to greater adiposity than are those with 2 wild-type alleles (TT). Objective: Because FTO is highly expressed in hypothalamic regions that are important for appetite, FTO genotype may affect energy balance by influencing eating behavior. OBJECTIVE—To examine the longitudinal association of fat mass-and obesity-associated (FTO) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse. RESEARCH DESIGN AND METHODS—We genotyped rs9939609 in 2,287 men and 3,520 women from two prospective cohorts.Plasma adiponectin and leptin were measured in a subset of diabetic men (n. FTO gene variants have been associated with obesity phenotypes in sedentary and obese populations, but rarely with skeletal muscle and elite athlete phenotypes. In 1089 participants, comprising 530 elite rugby athletes and 559 non-athletes, DNA was collected and genotyped for the FTO rs9939609 variant using real-time PCR. In a subgroup of non-resistance trained individuals (NT; n = 120), we.
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The FTO A/T polymorphism (rs9939609) has been strongly associated with body mass-related traits in nonathletic populations, but rarely with elite athletic performance. The aim of the study was to investigate the association between the A/T polymorphism and athlete status in elite swimmers. Women carrying the risk allele (TA or AA) of the FTO -rs9939609 genetic variant had a 1.16 kg/m 2 higher BMI over the follow-up period than those carrying the wild-type genotype (TT), even when. The FTO variant was significantly associated with body mass index (means in GG, GT and TT carriers were 28.7, 28.2 and 27.8 kg/m (2), p<0.001) and basal metabolic rate (BMR) (means in GG, GT and TT were 1603, 1588 and 1576 kcal per day, respectively, p<0.008) but it was not associated with physical activity, total energy intake or with energy in. Association of the following genotypes was seen in those with ≥5% weight loss: TT of FTO polymorphism; 35 (81.4%) [OR (95% CI) AT, 2.5 (0.6, 10.9); TT, 6.9 (1.6, 28.2); with reference to AA],.
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have been noted in several ethnic groups [22-27], includ-ing our previous report that FTO rs9939609 TT genotype was associated with obesity and preference for a high-fat diet in adult individuals from Jakarta [28]. Expression of the FTO gene also afects various parts of the brain that regulate energy balance and appetite [3, 29, 30]. Despite no evidence of any epistasis, we then went on to perform genotype combination analysis for rs9939609 and rs1544410, which showed that the FTO "AA" and VDR "CC" genotype combination and the FTO "TT" and VDR "CT" combination gave the highest and lowest mean BMI respectively (AA:CC-TT:CT; p = 0.016). This supports the fact.
However, when participants were stratified into higher and lower FTO methylation groups, the AA genotype possesses a 2.04-fold increased obesity risk in comparison to TT genotype (95%CI, 1.07-3.89. Second, SGA-naïve children with the FTO rs9939609 A allele had higher fasting plasma glucose concentrations than SGA-naïve children with the TT genotype. This association between FTO genotype and fasting plasma glucose was not seen in SGA-treated children, Third, as predicted, in a subset of the children, those with the FTO rs9939609 A allele.
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It has been found that food cravings declined with age, but this age effect was different across variants of FTO rs9939609, while TT homozygotes showed the typical age-related decline in food cravings, as well as no such decline among A-carriers. 31 Besides, the FTO genotype have effect on the relationship between age and emotional eating, with. All data were normally distributed according to the Shapiro-Wilk normality test. Regarding FTO rs9939609 genotype, about half of the participants were heterozygote (n = 98), about 30% of them were TT wild type (n = 60), and about 20% of them were AA homozygote (n = 38).The genotype distribution of the study population was in Hardy-Weinberg equilibrium.
