A Reed naevus is a very dark pigmented melanocytic naevus with spindle-shaped dermal melanocytes on histology. It was first reported by dermatologist Richard Reed in 1975. It is also known as a spindle cell naevus. Reed naevus is sometimes classified as a kind of Spitz naevus; the spindle-shaped cells of the Reed naevus may coexist with the. Differential diagnosis of Spitz and Reed naevi. The differential diagnosis of Spitz and Reed naevi includes acquired melanocytic naevi, blue naevi and melanoma.. Spitz tumours with kinase fusions. It has recently been shown that spitzoid neoplasms harbour kinase fusions of ROS1 (17%), NTRK1 (16%), ALK (10%), BRAF (5%) and RET (3%) in a mutually exclusive pattern.
Evolution of Reed Nevi Dermoscopic Pattern in Childhood Dermatology JAMA Dermatology JAMA
Spitz naevus is classified as classic, pigmented, or spindle cell tumour of Reed. The classic Spitz naevus is typically a dome-shaped red, reddish-brown papule. A pigmented Spitz naevus is a tan or brown papule or nodule. A pigmented spindle cell tumour of Reed is a bluish or black papule. There are clinical features in common for all three. Symmetric with cytologic maturation. Nests and fascicles of spindled melanocytes along dermoepidermal junction and within dermal papillae. May be junctional or compound. Expansive, not infiltrative growth pattern. Extends no deeper than reticular dermis. Nevus cells typically contain abundant melanin pigment, may be associated with melanophages. Pigmented spindle cell nevus is a benign melanocytic lesion that was initially described in 1975 by Reed et al. It is generally found on the trunk or lower extremities of young women. Most authors consider it to be a variant of Spitz nevus. The main concern with these lesions remains their propensity to mimic melanoma both clinically and histologically. Reed naevus; Meyerson naevus is a naevus affected by a halo of eczema / dermatitis. Halo naevus or Sutton naevus has a white halo around the mole. The mole gradually fades away over several years. Spitz naevus or epithelioid cell naevus is a pink (classic Spitz) or brown (pigmented Spitz) dome-shaped mole that arises in children and young adults.
Reed Nevus (Pigmented Spindle Cell Nevus) in an 11MonthOld Japanese Infant
The Spitz naevus (syn. spindle cell naevus, epithelioid cell naevus, juvenile melanoma) is a variant of a compound naevus and is most commonly seen in children . The pigmented spindle cell naevus of Reed (PSCNOR) is a variant of a compound or occasionally a junctional naevus. There is debate as to whether the PSCNOR is an entity in its own. The clinical-dermatoscopic-histological correlation of excised Spitz/Reed nevi revealed overlapping histopathological features among lesions displaying distinct dermatoscopic patterns ( Figures 1 - 3 ). Among lesions with histopathological atypia (16/47, 34.0%), all dermatoscopic patterns were represented, although the atypical/multicomponent. Reed nevus (also known as pigmented spindle cell nevus of Reed) is an acquired, benign, melanocytic lesion most frequently classified as a variant of a Spitz nevus. A Reed nevus typically presents as an asymptomatic, single, 2-8 mm, dark brown to black macule or papule on the lower extremities of young adults. The lesion may also be found in. Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society Br J Dermatol. 2017 Sep;177(3):645-655. doi: 10.1111/bjd.15339.. Nevus, Epithelioid and Spindle Cell / pathology Nevus, Epithelioid and Spindle Cell / therapy*.
Pigmented Spindle Cell Nevus of Reed Dermatopathology
Clinically, pigmented Spitz/Reed nevi are brown to black, flat to slightly elevated, symmetrical lesions showing a relative preference for certain locations, including face, limbs and buttocks. The most relevant and peculiar feature is the starburst pattern seen by dermoscopy. This is typified by multiple streaks of pigmentation or large. A Reed nevus is a dark brown or black, raised, dome-shaped mole that most often affects women. These moles can grow quickly and may be mistaken for melanoma. These moles can grow quickly and may.
The Reed Nevus or pigmented spindle cell nevus (PSCN) was first described by Reed et al. in 1975 . Its designation as a separate entity vs. a SN variant remains controversial, but is currently considered by the 2018 WHO Classification to be a "distinct variant of Spitz naevus.". Pigmented spindle cell nevus (PSCN) of Reed is a morphologic variant of Spitz and may be very diagnostically challenging, having histologic features concerning for melanoma. Their occurrence in younger patients, lack of association to sun exposure, and rapid early growth phase similar to Spitz nevi suggest fusions may also play a significant.
Clinical features and natural history of SpitzReed nevus in children. Semantic Scholar
'Nevus, Reed' published in 'Dermatopathology' Pigmented spindle cell nevus is a sharply demarcated and symmetrical melanocytic lesion characterized by a florid and cellular junctional component and marked melanin pigmentation (Fig. 1).The junctional aspect is composed of large and prominent nests containing uniform, spindled melanocytes arranged in fascicles with a characteristic vertical. Reed nevus is composed histologically of elongated spindle-shaped and nevoid cells with a benign biologic behavior. Histopathological features in common with Spitz nevi and in contrast with malignant melanoma include a relatively small size, lesion symmetry, uniformity of cell type, good circumscription, and maturation of cells from superficial.
