Koeppe's nodules are small nodules seen at the inner margin of the iris in patients with granulomatous anterior uveitis, which occurs in conditions such as sarcoidosis and tuberculosis. [1] The nodules are composed of epithelioid cells and giant cells surrounded by lymphocytes. [2] Koeppe's nodules are named after Leonhard Koeppe . References Sarcoid Uveitis. by Edmund Tsui, MD on September 19, 2023. Sarcoidosis is a systemic inflammatory disease characterized by the formation of noncaseating granulomas in affected organs, most commonly the lungs, lymph nodes, skin, and eyes. The disease was first described in 1878 by noted surgeon Sir Jonathan Hutchinson as a dermatologic disorder [1].
Multiple Koeppe nodules (white arrows) at iris pupillary border noted
Sarcoidosis is a systemic inflammatory disease of unknown etiology characterized by the formation of noncaseating granulomas. The disease most commonly affects the skin, lungs, lymph nodes, and eyes but can affect virtually any organ. Koeppe's Nodules May be found as: Koeppe nodules (inflammatory cell precipitates which lie at the pupillary margin and could be found in non-granulomaous as well as granulomatous uveitis) Bussaca nodules (lie on the iris surface) which are pathognomonic for granulomatous uveitis. When the inflammation is treated, the nodules will resolve. The Standardization of Uveitis Nomenclature (SUN) Working Group classifies onset as either "sudden," which is characterized by pain, redness and photophobia, or "insidious," where the eye is painless and white.2 • Duration. Objectives: Describe the pathogenesis of ocular sarcoidosis. Summarize the relevant history of patients with ocular sarcoidosis. Review the evaluation process of patients with ocular sarcoidosis. Outline the management of ocular sarcoidosis, including the role of interprofessional care of these patients.
FHU affecting the right eye with mild heterochromia. Both Koeppe (pupil
Iritis, also known as anterior uveitis, is the most common form of intra-ocular inflammation and often causes a painful red eye. The term uveitis is synonymous with inflammation of the uveal tract,. Iris nodules (Koeppe/Busacca) [Figures 5a and. Two types of iris nodules can develop in granulomatous uveitis. When situated at the pupillary margin (and on the surface of the iris) they are called Koeppe nodules, have a fluffy appearance and a size going from very small barely visible excresences to frank nodules. When situated in the body. Views 2884. Koeppe nodules in granulomatous uveitis. My Dashboard My Education Find an Ophthalmologist. Home. For Ophthalmologists. Meetings. AAO 2023. Meeting Information. Past and Future Meetings. Koeppe's nodules are small nodules seen at the inner margin of the iris in patients with granulomatous anterior uveitis, which occurs in conditions such as sarcoidosis and tuberculosis. The nodules are composed of epithelioid cells and giant cells surrounded by lymphocytes.
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Koeppe Nodules Koeppe's nodules are small nodules seen at the inner margin of the iris in patients with granulomatous anterior uveitis, which occurs in conditions sich as sarcoidosis and tuberculosis. iris nodules: Koeppe (small, near pupil), Bussaca (large, far from pupil) Anterior vitreous cells may be seen in iridocyclitis but often will indicate intermediate ± posterior uveitis Other signs include constricted or non-reactive pupil, iris atrophy, heterochromia, cataract, chronic corneal oedema including bullous keratopathy
The diseases most commonly associated with iris nodules and uveitis include sarcoidosis, Vogt-Koyanagi-Harada syndrome, multiple sclerosis, Fuchs' heterochromic iridocyclitis, and metastatic infection. In comparison, smaller koeppe nodules located on the pupillary border may be seen in both granulomatous and nongranulomatous irides. 7,8 Posterior segment involvement occurs in approximately one third of patients with ocular sarcoidosis, and typically presents as an intermediate uveitis. 3,7,8 Peripheral neovascularization, with or without.
Pupil margin (Koeppe) and iris surface (Busacca) nodules in a patient
Other features of granulomatous anterior uveitis include presence of Koeppe's nodules at the pupillary border and/or Busacca's nodules in the iris stroma. Nodules found at the pupillary border are known as Koeppe nodules and those found on the surface of the iris are referred to as Busaca nodules. 7. FUS is a clinical diagnosis, dependent on the eye examination. To detect the presence of rubella-specific antibodies, an anterior chamber paracentesis may be completed, however, this is not a.
